-
Ivana to give a talk at Duke Math Bio Seminar (Oct 2020)
-
Our paper is published in PNAS (Aug 2020)
-
Our paper is published in Nature Cancer (June 2020)
-
Ivana to give a Dartmouth Math Colloquium (May 2020)
-
Ivana to give a talk at Duke Math Bio Seminar (Oct 2020)
-
Our paper is published in PNAS (Aug 2020)
-
Our paper is published in Nature Cancer (June 2020)
-
Ivana to give a Dartmouth Math Colloquium (May 2020)
-
Ivana to give a talk at Duke Math Bio Seminar (Oct 2020)
-
Our paper is published in PNAS (Aug 2020)
-
Our paper is published in Nature Cancer (June 2020)
-
Ivana to give a Dartmouth Math Colloquium (May 2020)
Publications
[* joint first authors] [# corresponding author]
41. Accumulation of oncogenic mutations during progression from healthy tissue to cancer
R Zhang, I Bozic#.
bioRxiv 10.1101/2024.02.18.580841, 2024.
K Mamis, I Bozic#.
bioRxiv 10.1101/2024.01.26.577500, 2024.
K Mamis, R Zhang, I Bozic#.
Proceedings of the Royal Society B 290: 20231020, 2023.
D Woolston*, ND Lee*, M Shadman*, E Latorre-Esteves, XR Tee, J Fredrickson, BF Kohrn, O Sala-Torra, C Ujjani, A Eckel, B Till, M Fang, J Radich, I Bozic#, RA Risques#, CCS Yeung#
Haematologica 109, 835-845, 2023. [PDF]
37. Waiting times in a branching process model of colorectal cancer initiation
R Zhang, OA Ukogu, I Bozic#.
Theoretical Population Biology 151: 44-63, 2023. [PDF]
36. Clonal interactions in cancer: integrating quantitative models with experimental and clinical data.
ND Lee, K Kaveh, I Bozic#.
Seminars in Cancer Biology 92: 61-73, 2023.
E ten Hacken, T Sewastianik, S Yin, G Brunsting Hoffmann, M Gruber, K Clement, L Penter, RA Redd, N Ruthen, S Hergalant, A Sholokhova, G Fell, EM Parry, J Broseus, R Guieze, F Lucas, M Hernandez-Sanchez, K Baranowski, J Southard, H Joyal, L Billington, FFD Regis, E Witten, M Uduman, BA Knisbacher, S Li, H Lyu, T Vaisitti, S Deaglio, G Inghirami, P Feugier, S Stilgenbauer, E Tausch, MS Davids, G Getz, KJ Livak, I Bozic, DS Neuberg, R Carrasco, CJ Wu.
Blood Cancer Discovery 4: 1-20, 2023.
34. Inferring parameters of cancer evolution in chronic lymphocytic leukemia
ND Lee, I Bozic#.
PLOS Computational Biology 18: e1010677, 2022. [PDF]
33. A mechanistic model of malignant transformation in vestibular schwannoma
CGB Paterson, I Bozic, MJ Smith, X Hoad, DGR Evans
British Journal of Cancer 127: 1843–1857, 2022. [PDF]
O Kosterlitz, A Muñiz Tirado, C Wate, C Elg, I Bozic, EM Top, B Kerr
PLOS Biology 20: e3001732, 2022. [PDF]
I Bozic#.
Cancer Research 82: 21-24, 2022. [PDF]
30. Modelling CAR T-cell therapy with patient preconditioning
KL Owens, I Bozic#.
Bulletin of Mathematical Biology 83: 42, 2021. [PDF]
29. Mathematical model of colorectal cancer initiation
C Paterson, H Clevers#, I Bozic#.
Proc Natl Acad Sci USA 117: 20681-20688, 2020. [PDF] [software]
28. Delineating the evolutionary dynamics of cancer from theory to reality
Nature Cancer 1: 580-588, 2020. [PDF]
27. On measuring selection in cancer from subclonal mutation frequencies
I Bozic#, C Paterson, B Waclaw.
PLOS Computational Biology 15: e1007368, 2019. [PDF]
26. Growth dynamics in naturally progressing chronic lymphocytic leukaemia
M Gruber*, I Bozic*, I Leshchiner*, D Livitz*, K Stevenson, L Rassenti, D Rosebrock, A Taylor-Weiner, O Olive, R Goyetche, SM Fernandes, J Sun, C Stewart, A Wong, C Cibulskis, W Zhang, JG Reiter, JM Gerold, JG Gribben, KR Rai, MJ Keating, JR Brown, D Neuberg, TJ Kipps, MA Nowak, G Getz, CJ Wu.
I Leshchiner, D Livitz, JF Gainor, D Rosebrock, O Spiro, A Martinez, E Mroz, JJ Lin, C Stewart, J Kim, L Elagina, I Bozic, M Mino-Kenudson, M Rooney, SH Ignatius Ou, CJ Wu, JW Rocco, JA Engelman, AT Shaw, G Getz.
bioRxiv 2019 [pdf]
24. Dormant tumour cells, their niches and the influence of immunity
ET Goddard, I Bozic, SR Riddell, CM Ghajar.
Nature Cell Biology 20: 1240-1249, 2018. [PDF]
23. The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy
DA Landau, C Sun, D Rosebrock, SEM Herman, J Fein, M Sivina, C Underbayev, D Liu, J Hoellenriegel, S Ravichandran, MZH Farooqui, W Zhang, C Cibulskis, A Zviran, DS Neuberg, D Livitz, I Bozic, I Leshchiner, G Getz, JA Burger, A Wiestner, CJ Wu.
Nature Communications 8: 2185, 2017. [PDF]
I Bozic#, MA Nowak#.
Annual Review of Cancer Biology 1: 203-221, 2017. [PDF]
21. Reconstructing metastatic seeding patterns of human cancers
JG Reiter, AP Makohon-Moore, JM Gerold, I Bozic, K Chatterjee, CA Iacobuzio-Donahue, B Vogelstein, MA Nowak.
Nature Communications 8: 14114, 2017. [PDF]
AP Makohon-Moore, M Zhang, JG Reiter, I Bozic, B Allen, D Kundu, K Chatterjee, F Wong, Y Jiao, LD Wood, RH Hruban, MA Nowak, N Papadopoulos, KW Kinzler, B Vogelstein, CA Iacobuzio-Donahue.
Nature Genetics 49: 358-366, 2017. [PDF]
19. Tumor and immune cell dynamics explain the PSA bounce after prostate cancer brachytherapy
Y Yamamoto, CP Offord, G Kimura, S Kuribayashi, H Takeda, S Tsuchiya, H Shimojo, H Kanno, I Bozic, MA Nowak, Ž Bajzer, D Dingli. British Journal of Cancer 115: 195-202, 2016. [PDF]
JA Burger*, DA Landau*, AN Taylor-Weiner*, I Bozic*, H Zhang*, K Sarosiek, L Wang, C Stewart, J Fan, J Hoellenriegel, M Sivina, AM Dubuc, C Fraser, Y Han, S Li, KJ Livak, L Zou, YWan, S Konoplev, C Sougnez, LV Abruzzo, SL Carter, MJ Keating, MS Davids, WG Wierda, K Cibulskis, T Zenz, L Werner, P Dal Cin, P Kharchencko, D Neuberg, H Kantarjian, E Lander, S Gabriel, S O’Brien, A Letai, DA Weitz, MA Nowak, G Getz, CJ Wu.
Nature Communications 7: 11589, 2016. [PDF]
17. Quantifying clonal and subclonal passenger mutations in cancer evolution
I Bozic#, JM Gerold, MA Nowak#.
PLOS Computational Biology 12: e1004731, 2016. [PDF]
16. Mutations driving CLL and their evolution in progression and relapse
DA Landau, E Tausch, AN Taylor-Weiner, C Stewart, JG Reiter, J Bahlo, S Kluth, I Bozic, M Lawrence, S Bottcher, SL Carter, K Cibulskis, D Mertens, C Sougnez, M Rosenberg, JM Hess, J Edelmann, S Kless, M Kneba, M Ritgen, A Fink, K Fischer, S Gabriel, E Lander, MA Nowak, H Dohner, M Hallek, D Neuberg, G Getz, S Stilgenbauer, CJ Wu.
Nature 526: 525-530, 2015. [PDF]
15. Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers
S Misale*, I Bozic*, JS Tong, A Peraza-Penton, A Lallo, F Baldi, K Lin, M Truini, L Trusolino, A Bertotti, F Di Nicolantonio, MA Nowak, L Zhang, K Wood, A Bardelli.
Nature Communications 6: 8305, 2015. [PDF]
14. A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity
B Waclaw, I Bozic, ME Pittman, RH Hruban, B Vogelstein, MA Nowak.
Nature 525: 261-264, 2015. [PDF]
13. The (not so) immortal strand hypothesis
C Tomasetti, I Bozic.
Stem Cell Research 14: 238-241, 2015. [PDF]
12. Timing and heterogeneity of mutations associated with drug resistance in metastatic cancers
I Bozic#, MA Nowak#.
Proc Natl Acad Sci USA 111: 15964-15968, 2014. [PDF] [Supplement]
10. Evolutionary dynamics of cancer in response to targeted combination therapy
I Bozic*, JG Reiter*, B Allen*, T Antal, K Chatterjee, P Shah, YS Moon, A Yaqubie, N Kelly, DT Le, EJ Lipson, PB Chapman, LA Diaz Jr, B Vogelstein, MA Nowak.
eLife 2: e00747, 2013. [PDF] [Supplement]
9. TTP: Tool for tumor progression
JG Reiter, I Bozic, K Chatterjee, MA Nowak.
In Proceedings of 25th International Conference on Computer Aided Verification, Lecture Notes in Computer Science 8044: 101-106, 2013. [PDF]
8. The effect of one additional driver mutation on tumor progression
JG Reiter*, I Bozic*, B Allen, K Chatterjee, MA Nowak.
Evolutionary Applications 6: 34-45, 2013. [PDF]
7. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
LA Diaz Jr, R Williams, J Wu, J R Hecht, J Berlin, B Allen, I Bozic, JG Reiter, MA Nowak, KW Kinzler, KS Oliner, B Vogelstein.
Nature 486: 537-540, 2012. [PDF]
6. Dynamics of targeted cancer therapy
I Bozic, B Allen, MA Nowak.
Trends in Molecular Medicine 18: 311-316, 2012.
5. Distant metastasis occurs late during the genetic evolution of pancreatic cancer
S Yachida, S Jones, I Bozic, T Antal, R Leary, B Fu, M Kamiyama, RH Hruban, JR Eshleman, MA Nowak, VE Velculescu, KW Kinzler, B Vogelstein, CA Iacobuzio-Donahue.
Nature 467: 1114-1117, 2010. [PDF]
4. Accumulation of driver and passenger mutations during tumor progression
I Bozic, T Antal, H Ohtsuki, H Carter, D Kim, S Chen, R Karchin, KW Kinzler, B Vogelstein, MA Nowak.
Proc Natl Acad Sci USA 107: 18545-18550, 2010. [PDF]
3. Zero-divisor graphs of matrices over commutative rings
I Bozic, Z Petrovic.
Communications in Algebra 37: 1186-1192, 2009.
2. Prediction of supertype-specific HLA class I binding peptides using support vector machines
GL Zhang, I Bozic, CK Kwoh, JT August, V Brusic. .
Journal of Immunological Methods 320: 143-154, 2007.
1. Predictive vaccinology: optimization of predictions using support vector machine classifiers
I Bozic, GL Zhang, V Brusic.
In Proceedings of the 6th International Conference on Intelligent Data Engineering and Automated Learning, Lecture Notes in Computer Science 3578: 375-381, 2005.